Modulation by propranolol of the lysyl cross-links in aortic elastin and collagen of the aneurysm-prone turkey
| Autor: | Zeenat Gunja-Smith, Robert J. Boucek, Charles F. Simpson, Nancy L. Noble |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Turkeys
medicine.medical_specialty Blood Pressure Lysyl oxidase Propranolol Biochemistry chemistry.chemical_compound Aneurysm Heart Rate Tensile Strength Internal medicine medicine.artery Ultimate tensile strength Heart rate medicine Animals Aorta Abdominal Pharmacology Pyridinoline biology Chemistry Lysine Abdominal aorta Arteries medicine.disease Elastin Endocrinology biology.protein Female Collagen medicine.drug |
| Zdroj: | Biochemical Pharmacology. 32:275-280 |
| ISSN: | 0006-2952 |
| DOI: | 10.1016/0006-2952(83)90555-5 |
| Popis: | dl-Propranolol (propranolol) fed to immature and mature aneurysm-prone turkeys (Broad-Breasted White, BBW) for 6 weeks significantly raised the tensile strength of tissue rings from the abdominal aorta. The drug-mediated increase in tensile strength values was dose-related and independent of its heart rate- and arterial pressure-lowering effects. Propranolol acts, in part, by (a) stimulating lysyl oxidase to produce greater amounts of reactive aldehydes for intermolecular cross-links, (b) enhancing the progression of chemically unstable to stable forms of intermolecular elastin cross-links (lysinonorleucine and the desmosines), and (c) reducing the density of the age-related intermolecular cross-linking of collagen (pyridinoline). These propranolol effects on the lysyl cross-links were demonstrated in both the immature and mature animals and suggest a heretofore unrecognized potential for this widely used cardiovascular drug. |
| Databáze: | OpenAIRE |
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