Complete amino acid sequence of a unique protein related to the variable domain of lambda light chain from a case with Fanconi syndrome
| Autor: | Akihiko Hoshi, Takashi Isobe, Tomotaka Shinoda, Fuyuki Kametani, Hiroshi Tonoike, Kazunori Yoshimura |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Chemical Phenomena
Stereochemistry Biophysics Biology Immunoglobulin lambda-Chains Immunoglobulin light chain Biochemistry chemistry.chemical_compound medicine Humans Trypsin Amino Acid Sequence Amino Acids Molecular Biology Peptide sequence Sequence (medicine) chemistry.chemical_classification Fanconi syndrome Cell Biology Middle Aged medicine.disease Fanconi Syndrome Amino acid Chemistry Proteinuria Monomer chemistry Female Immunoglobulin Light Chains Multiple Myeloma medicine.drug |
| Zdroj: | Biochemical and biophysical research communications. 126(2) |
| ISSN: | 0006-291X |
| Popis: | The complete amino acid sequence has been determined of a unique protein from a 55-years-old female with multiple myeloma associated with Fanconi syndrome. It existed in a monomer form with an apparent molecular weight of 10K daltons, and was consisted of 106 amino acid residues. The sequence was characteristic of the V-region of lambda light chains and was highly homologous with that of the first 106 residues of V lambda III subgroup. The presence of an intact light chain as well as a 13K daltons fragment, corresponding to the entire C-region, strongly suggests that the unique component is a catabolic product from the intact light chain rather than an aberrant product of synthesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|