Use of NMR imaging in the optimization of a compression-coated regulated release system
| Autor: | Colin A. Fyfe, Brian J Fahie, Hiltrud Grondey, Nangia Avinash Kumar, Sham Chopra, Almira Blazek |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Active ingredient
Materials science Surface Properties Pharmaceutical Science Mineralogy Core (manufacturing) Lactose engineering.material Ranitidine Magnetic Resonance Imaging Dosage form Chemical engineering Coating Histamine H2 Antagonists Delayed-Action Preparations engineering Pressure Liberation Molecule Methacrylates Porosity Cellulose Dissolution Tablets |
| Zdroj: | Journal of controlled release : official journal of the Controlled Release Society. 51(2-3) |
| ISSN: | 0168-3659 |
| Popis: | Nuclear magnetic resonance (NMR) imaging is routinely used to detect the protons of mobile water molecules within samples. In this investigation, this non-destructive, non-invasive technique was used to determine the cause for faster than predicted drug release from a dissolution-based regulated-release tablet. The NMR images of tablets, from two different formulations, taken at various intervals of time while immersed in static USP dissolution medium showed that the tablet with faster than predicted drug release had a porous coating. The porous coat exposed more of the core surface area to the dissolution medium than desired and this caused an increase in the rate of dissolution of the core. The data presented in this paper demonstrate the usefulness of NMR imaging in solid dosage form development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect