Special issue 'The advance of solid tumor research in China': Multi‐omics analysis based on 1311 clear cell renal cell carcinoma samples identifies a glycolysis signature associated with prognosis and treatment response

Autor: Xi Tian, Yue Wang, Wenhao Xu, Haidan Tang, Shuxuan Zhu, Aihetaimujiang Anwaier, Wangrui Liu, Wenfeng Wang, Wenkai Zhu, Jiaqi Su, Yuanyuan Qu, Hailiang Zhang, Dingwei Ye
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Cancer. 152:66-78
ISSN: 1097-0215
0020-7136
Popis: In clear cell renal cell carcinoma (ccRCC), glycolysis is enhanced mainly because of the increased expression of key enzymes in glycolysis. Hence, the discovery of new molecular biomarkers for glycolysis may help guide and establish a precise system of diagnosis and treatment for ccRCC. Expression profiles of 1079 tumor samples of ccRCC patients (including 311 patients treated with everolimus or nivolumab) were downloaded from public databases. Proteomic profiles of 232 ccRCC samples were obtained from Fudan University Shanghai Cancer Center (FUSCC). Biological changes, tumor microenvironment and prognostic differences were explored between samples with various glycolysis characteristics. There were significant differences in CD8
Databáze: OpenAIRE
Externí odkaz: