Short-term exposure to pollen and the risk of allergic and asthmatic manifestations: a systematic review and meta-analysis
| Autor: | Timo T. Hugg, Milja A Kitinoja, Maritta S. Jaakkola, Jouni J. K. Jaakkola, Daniel Rodriguez Yanez, Nazeeba Siddika |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Allergy Epidemiology medicine.disease_cause Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Risk Factors Pollen Internal medicine medicine Hypersensitivity Prevalence Humans 030212 general & internal medicine Lung function Asthma business.industry public health General Medicine Environmental Exposure Allergens asthma medicine.disease allergy Respiratory Function Tests 030228 respiratory system Meta-analysis Seasons business Relevant information Systematic search |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | BackgroundSeveral studies have assessed effects of short-term exposure to pollen on allergic and asthmatic manifestations. The evidence is inconclusive, and no meta-analysis has been published.ObjectiveTo synthesise the evidence on the relations between short-term pollen exposure and the risk of allergic and asthmatic manifestations.MethodsWe performed a systematic literature search of PubMed and Scopus databases up to the end of August 2018. In addition, we reviewed the reference lists of relevant articles. Two authors independently evaluated the eligible articles and extracted relevant information in a structured form. We calculated summary effect estimates (EE) based on the study-specific ORs and regression coefficients (β) by applying both fixed-effects and random-effects models.Results26 studies met the a priori eligibility criteria, and 12 of them provided sufficient information for the meta-analysis. The summary EE related to 10 grains per m³ increase in pollen exposure showed an 1% increase (EE 1.01, 95% CI 1.00 to 1.02) in the risk of lower respiratory symptoms and a 2% increase (EE 1.02, 95% CI 1.01 to 1.03) in the risk of any allergic or asthmatic symptom. Correspondingly, the risk of upper respiratory symptoms and ocular symptoms increased 7% (EE 1.07, 95% CI 1.04 to 1.09) and 11% (EE 1.11, 95% CI 1.05 to 1.17), respectively, in relation to such pollen exposure. Short-term exposure to pollen did not show any significant effect on daily lung function levels.ConclusionOur results provide new evidence that short-term pollen exposure significantly increases the risks of allergic and asthmatic symptoms. |
| Databáze: | OpenAIRE |
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