Signalling Pathways that Inhibit the Capacity of Precursor Cells for Myelin Repair
| Autor: | Holly S. Cate, Jennifer K. Sabo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Multiple Sclerosis
Cell Transplantation Review Biology bone morphogenic protein (BMP) Catalysis Inorganic Chemistry lcsh:Chemistry Myelin central nervous system (CNS) Neural Stem Cells Precursor cell medicine Animals Humans Physical and Theoretical Chemistry Remyelination Demyelinating Disorder Molecular Biology lcsh:QH301-705.5 Spectroscopy Myelin Sheath Regeneration (biology) Multiple sclerosis Organic Chemistry neural precursor cell (NPC) General Medicine oligodendrocyte progenitor cell (OPC) medicine.disease Oligodendrocyte Neural stem cell Computer Science Applications Cell biology Nerve Regeneration Oligodendroglia medicine.anatomical_structure lcsh:Biology (General) lcsh:QD1-999 Immunology Demyelinating Diseases Signal Transduction |
| Zdroj: | International Journal of Molecular Sciences, Vol 14, Iss 1, Pp 1031-1049 (2013) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | In demyelinating disorders such as Multiple Sclerosis (MS), targets of injury are myelin and oligodendrocytes, leading to severe neurological dysfunction. Regenerative therapies aimed at promoting oligodendrocyte maturation and remyelination are promising strategies for treatment in demyelinating disorders. Endogenous precursor cells or exogenous transplanted cells are potential sources for remyelinating oligodendrocytes in the central nervous system (CNS). Several signalling pathways have been implicated in regulating the capacity of these cell populations for myelin repair. Here, we review neural precursor cells and oligodendrocyte progenitor cells as potential sources for remyelinating oligodendrocytes and evidence for the functional role of key signalling pathways in inhibiting regeneration from these precursor cell populations. |
| Databáze: | OpenAIRE |
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