Centromere Protein I (CENP-I) Is Upregulated in Gastric Cancer, Predicts Poor Prognosis, and Promotes Tumor Cell Proliferation and Migration
| Autor: | Jian Chen, Ning Li, Xin Liu, Hongjin Chu, Jiahui Wang, Liu-Ye Huang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Cancer Research Poor prognosis mitotic checkpoints Tumor cells Apoptosis macromolecular substances Biology centromere protein I Centromere protein I Downregulation and upregulation Cell Movement Stomach Neoplasms medicine Biomarkers Tumor Tumor Cells Cultured Lauren classification Humans RC254-282 Cell Proliferation Mitotic Checkpoints proliferative subtype gastric cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cancer Middle Aged medicine.disease Prognosis DNA-Binding Proteins Gene Expression Regulation Neoplastic Oncology Case-Control Studies Cancer research Female Original Article Function (biology) |
| Zdroj: | Technology in Cancer Research & Treatment Technology in Cancer Research & Treatment, Vol 20 (2021) |
| ISSN: | 1533-0338 |
| Popis: | This study aimed to investigate the expression and cellular function of the centromeric family of proteins (CENPs), especially centromere protein I (CENP-I), in gastric cancer (GC) and identified its clinical significance and cellular functions. CENP-I expression in GC was studied by cDNA microarray, quantitative real-time PCR (qRT-PCR), and immunohistochemistry (IHC), and using datasets from The Cancer Genome Atlas (TCGA), UALCAN, and Gene Expression Omnibus (GEO) databases. Microarray and bioinformatic analyses identified upregulated CENP-A/E/F/H/I/K/P/W and HJURP in stomach adenocarcinoma (STAD), but not in signet ring cell carcinoma (SRCC). Significantly higher CENP-I mRNA expression was also confirmed in 40 pairs of GC tissues than in paired normal gastric tissues by qRT-PCR ( P |
| Databáze: | OpenAIRE |
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