Outcome of concomitant treatment with thiopurines and allopurinol in patients with inflammatory bowel disease:A nationwide Danish cohort study
| Autor: | Kristine H. Allin, Johan Burisch, Tine Jess, Klaus Theede, Susanne Hansen, Sandra Bohn Thomsen, Camilla B. Jensen, Lise Lotte Gluud, Marianne Kiszka-Kanowitz, Anette Mertz Nielsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Denmark Severity of Illness Index Inflammatory bowel disease surgery 0302 clinical medicine Crohn Disease Azathioprine Epidemiology Thiopurine methyltransferase biology Mercaptopurine Remission Induction Gastroenterology Middle Aged Hospitalization Treatment Outcome Oncology 030220 oncology & carcinogenesis language Drug Therapy Combination Female 030211 gastroenterology & hepatology epidemiology Immunosuppressive Agents Signal Transduction medicine.drug Cohort study hospitalization Adult musculoskeletal diseases medicine.medical_specialty Allopurinol allopurinol Danish 03 medical and health sciences Internal medicine thiopurine medicine Humans In patient Thioguanine business.industry Original Articles medicine.disease language.human_language anti-TNF alpha Concomitant biology.protein Colitis Ulcerative business Follow-Up Studies |
| Zdroj: | Thomsen, S B, Allin, K H, Burisch, J, Jensen, C B, Hansen, S, Gluud, L L, Theede, K, Kiszka-Kanowitz, M, Nielsen, A M & Less, T 2020, ' Outcome of concomitant treatment with thiopurines and allopurinol in patients with inflammatory bowel disease : A nationwide Danish cohort study ', European Journal of Gastroenterology and Hepatology, vol. 8, no. 1, pp. 68-76 . https://doi.org/10.1177/2050640619868387 |
| DOI: | 10.1177/2050640619868387 |
| Popis: | BACKGROUND: Thiopurine and allopurinol in combination are associated with clinical remission in inflammatory bowel diseases but their influence on subsequent outcomes is unclear. We compared outcomes during exposure to both thiopurines and allopurinol versus thiopurines alone. METHODS: We established a nationwide cohort of patients with inflammatory bowel diseases exposed to thiopurines ± allopurinol during 1999–2014, using registry data. Patients were followed until hospitalization, surgery, anti-TNFα, or death (as a primary composite outcome). We used Poisson regression analyses to calculate incidence rate ratios overall and stratified by calendar period (assuming the combined exposure was unintended before 2009). RESULTS: A total of 10,367 patients with inflammatory bowel diseases (Crohn's disease, n = 5484; ulcerative colitis, n = 4883) received thiopurines. Of these, 217 (2.1%) also received allopurinol. During 24,714 person years of follow-up, we observed 40 outcomes among thiopurine-allopurinol-exposed patients, and 4745 outcomes among those who were thiopurine exposed; incidence rate ratio, 1.26 (95% confidence interval, 0.92–1.73). The incidence rate ratios decreased over time: 4.88 (95% confidence interval 2.53–9.45) for 1999–2003, 2.19 (95% confidence interval, 1.17–4.09) for 2004–2008 and 0.80 (95% confidence interval, 0.52–1.23) for 2009–2014. CONCLUSION: Our nationwide inflammatory bowel disease cohort study shows that concomitant thiopurine-allopurinol is as safe to use as thiopurines alone, with a tendency towards a positive effect on clinical outcomes in recent calendar periods when combined use was intended. |
| Databáze: | OpenAIRE |
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