Uremic toxins activate CREB/ATF1 in endothelial cells related to chronic kidney disease

Autor:	Regiane Stafim da Cunha, Paulo Cézar Gregório, Rayana Ariane Pereira Maciel, Giane Favretto, Célia Regina Cavichiolo Franco, Jenifer Pendiuk Gonçalves, Marina Luise Viola de Azevedo, Roberto Pecoits-Filho, Andréa Emilia Marques Stinghen
Rok vydání:	2022
Předmět:	Male Pharmacology Cyclooxygenase 2 Endothelial Cells Humans Female Uremic Toxins Vascular Diseases Renal Insufficiency Chronic Indican Biochemistry
Zdroj:	Biochemical Pharmacology. 198:114984
ISSN:	0006-2952
Popis:	Uremic toxins, such as p-cresyl sulfate (PCS) and indoxyl sulfate (IS), contribute to endothelial dysfunction in chronic kidney disease (CKD). This process is mediated by several cellular pathways, but it is unclear whether cAMP-responsive element-binding protein (CREB) and activating transcription factor 1 (ATF1) participate in endothelial dysfunction in uremic conditions despite playing roles in inflammatory modulation. This study aimed to evaluate the expression, activation, and transcriptional activity of CREB/ATF1 in endothelial cells exposed to PCS, IS, and uremic serum (US). In vitro, ATF1 protein levels were increased by PCS and IS, whereas CREB levels were enhanced only by IS. Activation through CREB-Ser
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b925a3240644b18c22c2cf526507df https://doi.org/10.1016/j.bcp.2022.114984 Zobrazit plný text záznamu Full Text from ScienceDirect