Anemia and Iron Deficiency in Outpatients with Inflammatory Bowel Disease: Ubiquitous Yet Suboptimally Managed
| Autor: | Loveikyte, R., Boer, M., Meulen, C.N. van der, Steege, R.W.F. ter, Tack, G., Kuyvenhoven, J., Jharap, B., Vu, M.K., Vogelaar, L., West, R.L., Marel, S. van der, Romkens, T.E.H., Mujagic, Z., Hoentjen, F., Bodegraven, A.A. van, Schaik, F.D.M. van, Vries, A.C. de, Dijkstra, G., Meulen-de Jong, A.E. van der, Dutch Initiative Crohn Colitis ICC |
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| Přispěvatelé: | Gastroenterology & Hepatology, MUMC+: MA Maag Darm Lever (9), RS: NUTRIM - R2 - Liver and digestive health, Interne Geneeskunde, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Gastroenterology and hepatology, Amsterdam Gastroenterology Endocrinology Metabolism |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Clinical Medicine, 11 Journal of Clinical Medicine, 11(22):6843. Multidisciplinary Digital Publishing Institute (MDPI) Journal of Clinical Medicine, 11(22). Multidisciplinary Digital Publishing Institute (MDPI) Journal of Clinical Medicine, 11, 22 Journal of Clinical Medicine; Volume 11; Issue 22; Pages: 6843 Clinical Chemistry, 11(22):6843 Journal of Clinical Medicine, 11(22):6843. MDPI AG Journal of Clinical Medicine, 11(22). MDPI |
| ISSN: | 2077-0383 0009-9147 |
| Popis: | BACKGROUND: Iron deficiency (ID) and anemia in patients with Inflammatory Bowel Disease (IBD) are associated with a reduced quality of life. We assessed the prevalence of ID and anemia in Dutch outpatients with IBD and compared routine ID(A) management among medical professionals to the European Crohn's and Colitis Organisation (ECCO) treatment guidelines.METHODS: Between January and November 2021, consecutive adult outpatients with IBD were included in this study across 16 Dutch hospitals. Clinical and biochemical data were extracted from medical records. Additionally, medical professionals filled out questionnaires regarding routine ID(A) management.RESULTS: In total, 2197 patients (1271 Crohn's Disease, 849 Ulcerative Colitis, and 77 IBD-unclassified) were included. Iron parameters were available in 59.3% of cases. The overall prevalence of anemia, ID, and IDA was: 18.0%, 43.4%, and 12.2%, respectively. The prevalence of all three conditions did not differ between IBD subtypes. ID(A) was observed more frequently in patients with biochemically active IBD than in quiescent IBD (ID: 70.8% versus 23.9%; p < 0.001). Contrary to the guidelines, most respondents prescribed standard doses of intravenous or oral iron regardless of biochemical parameters or inflammation. Lastly, 25% of respondents reported not treating non-anemic ID.CONCLUSIONS: One in five patients with IBD suffers from anemia that-despite inconsistently measured iron parameters-is primarily caused by ID. Most medical professionals treat IDA with oral iron or standard doses of intravenous iron regardless of biochemical inflammation; however, non-anemic ID is often overlooked. Raising awareness about the management of ID(A) is needed to optimize and personalize routine care. |
| Databáze: | OpenAIRE |
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