AKI persistence at 48 h predicts mortality in patients with acute on chronic liver failure
| Autor: | Ajeet Singh Bhadoria, Guresh Kumar, Pooja Jain, Ankit Bharadwaj, Kapil Dev Jamwal, Rakhi Maiwall, Shiv Kumar Sarin |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Liver Cirrhosis Male medicine.medical_specialty Time Factors Gastroenterology Sensitivity and Specificity Severity of Illness Index End Stage Liver Disease 03 medical and health sciences Liver disease chemistry.chemical_compound 0302 clinical medicine Risk Factors Internal medicine medicine Humans Hospital Mortality Prospective Studies Proportional Hazards Models Creatinine Hepatology business.industry Hazard ratio Acute kidney injury Age Factors Acute-On-Chronic Liver Failure Odds ratio Acute Kidney Injury Middle Aged medicine.disease Confidence interval Systemic Inflammatory Response Syndrome Systemic inflammatory response syndrome 030104 developmental biology chemistry 030211 gastroenterology & hepatology Female business |
| Zdroj: | Hepatology international. 11(6) |
| ISSN: | 1936-0541 |
| Popis: | Management of acute kidney injury (AKI) in cirrhotics has undergone a paradigm change. We evaluated the impact of AKI persistence at 48 h on outcome in patients with acute on chronic liver failure (ACLF). Consecutive patients with ACLF (n = 373) were prospectively followed. AKI was defined as increase in serum creatinine of 0.3 mg/dl or 1.5- to 2-fold from baseline. Persistent AKI was defined as nonresponsive AKI at 48 h with respect to admission serum creatinine. AKI at admission was present in 177 (47.5 %) patients. At 48 h, 73 % patients had persistent AKI and 27 % had responsive AKI. High Model for End-Stage Liver Disease (MELD) (≥26) [p, odds ratio (OR), 95 % confidence interval (CI)] [ |
| Databáze: | OpenAIRE |
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