Cranial and intra-axial metastasis originating from a primary ovarian Dysgerminoma☆
| Autor: | Jeffrey M. Dym, Bram H. Goldstein, Vikas Y. Rao, Tiffany L. Beck, Hitomi Momose, Randy Bohart |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Cranial metastasis medicine.medical_treatment Case Report Bleomycin lcsh:Gynecology and obstetrics lcsh:RC254-282 Metastasis Ovarian dysgerminoma 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Stage (cooking) Etoposide lcsh:RG1-991 Chemotherapy 030219 obstetrics & reproductive medicine business.industry Meninges Obstetrics and Gynecology medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Pancytopenia Treatment medicine.anatomical_structure Oncology chemistry 030220 oncology & carcinogenesis Radiology Germ cell tumors business medicine.drug |
| Zdroj: | Gynecologic Oncology Reports Gynecologic Oncology Reports, Vol 29, Iss, Pp 55-57 (2019) |
| ISSN: | 2352-5789 |
| Popis: | Dysgerminomas are aggressive germ cell tumors that typically have a favorable prognosis, especially in patients diagnosed with early stage disease. We recount the history of a 23-year-old woman who was treated for a stage IA ovarian dysgerminoma in November 2017. Postoperatively, the patient was noncompliant insofar as obtaining routine lab evaluations; ten months later, she was diagnosed with a cranial metastasis that extended into the meninges. The patient subsequently underwent a posterior fossa craniotomy and adjuvant etoposide, bleomycin and cisplatin chemotherapy to which she initially responded; however, during cycle 4, she developed pancytopenia whereupon the chemotherapy was summarily discontinued. Thereafter, the patient was surveilled and currently, she remains in clinical remission. Early stage ovarian dysgerminoma, albeit rarely, has the capacity to metastasize to the cranium or brain, further underscoring the significance of employing active follow-up with these patients. Highlights • Dysgerminomas often afflict young adults and can exhibit a rapid growth pattern. • We describe a dysgerminoma patient who developed an cranial and intra-axial metastasis. • The patient initially responded to adjuvant therapy and is currently being surveilled. |
| Databáze: | OpenAIRE |
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