Canadian economic impact of improved workplace productivity in patients with major depressive disorder treated with vortioxetine
| Autor: | Julie Patenaude, Jean Lachaine, Joanna Bougie, Pratap Chokka, Joëlle Bibeau, Catherine Beauchemin, Jean Proulx |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Gerontology Canada Efficiency Cognition Return to Work medicine Humans In patient Economic impact analysis Major depressive episode Productivity Work Performance Vortioxetine Depressive Disorder Major business.industry Middle Aged medicine.disease Antidepressive Agents Psychiatry and Mental health Presenteeism Absenteeism Major depressive disorder Female Neurology (clinical) medicine.symptom business |
| Zdroj: | CNS Spectrums. 25:372-379 |
| ISSN: | 2165-6509 1092-8529 |
| DOI: | 10.1017/s1092852919000853 |
| Popis: | Objective.The AtWoRC study is an interventional, open-label Canadian study that demonstrated significant improvements in cognitive function and workplace productivity in patients with major depressive disorder (MDD) treated with vortioxetine for a current major depressive episode. The objective of the present analysis was to assess the Canadian economic impact of improved workplace productivity based on the AtWoRC study results.Methods.The economic impact of improved productivity in patients with MDD treated with vortioxetine was assessed over a 52-week period considering productivity loss due to absenteeism and presenteeism using the standard human capital approach and an employer’s perspective. Absenteeism was measured with the Work Productivity and Activity Impairment questionnaire; and presenteeism with the Work Limitation Questionnaire. Productivity gains following treatment initiation with vortioxetine were estimated using the difference from baseline.Results.In the AtWoRC study, patients at baseline reportedly missed, in the past 7 days, an average of 8.1 h due to absenteeism and 3.0 h due to presenteeism. Following 52 weeks of treatment with vortioxetine, patients reportedly missed an average of 4.9 h due to absenteeism and 2.0 h due to presenteeism. This improved workplace productivity translated into savings of C$110.64 for 1 week of work following 52 weeks of treatment. The cumulative 52-week economic impact showed potential savings of C$4,550 when factoring in the cost of therapy.Conclusion.This study suggested that workplace productivity gain due to an improvement in symptoms of MDD following treatment with vortioxetine will lead to substantial cost savings for the Canadian economy. |
| Databáze: | OpenAIRE |
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