Effect of transcranial direct current stimulation on in-vivo assessed neuro-metabolites through magnetic resonance spectroscopy: a systematic review
| Autor: | Janardhanan C Narayanswamy, Harleen Chhabra, Ganesan Venkatasubramanian, Venkataram Shivakumar, Vani Holebasavanahalli Thimmashetty |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Magnetic Resonance Spectroscopy medicine.medical_treatment Population Baseline level Transcranial Direct Current Stimulation Cerebellar Cortex 03 medical and health sciences Dorsolateral Prefrontal Cortex 0302 clinical medicine Physical medicine and rehabilitation Parietal Lobe medicine Humans education Potential mechanism gamma-Aminobutyric Acid Biological Psychiatry Aged education.field_of_study Transcranial direct-current stimulation business.industry Mental Disorders Transcranial Magnetic Stimulation Temporal Lobe 030227 psychiatry Psychiatry and Mental health Case-Control Studies Female Nervous System Diseases business 030217 neurology & neurosurgery |
| Zdroj: | Acta Neuropsychiatrica. 33:242-253 |
| ISSN: | 1601-5215 0924-2708 |
| DOI: | 10.1017/neu.2021.14 |
| Popis: | Objectives:Previous studies have examined the effect of transcranial direct current stimulation (tDCS) on the in-vivo concentrations of neuro-metabolites assessed through magnetic resonance spectroscopy (MRS) in neurological and psychiatry disorders. This review aims to systematically evaluate the data on the effect of tDCS on MRS findings and thereby attempt to understand the potential mechanism of tDCS on neuro-metabolites.Methods:The relevant literature was obtained through PubMed and cross-reference (search till June 2020). Thirty-four studies were reviewed, of which 22 reported results from healthy controls and 12 were from patients with neurological and psychiatric disorders.Results:The evidence converges to highlight that tDCS modulates the neuro-metabolite levels at the site of stimulation, which, in turn, translates into alterations in the behavioural outcome. It also shows that the baseline level of these neuro-metabolites can, to a certain extent, predict the outcome after tDCS. However, even though tDCS has shown promising effects in alleviating symptoms of various psychiatric disorders, there are limited studies that have reported the effect of tDCS on neuro-metabolite levels.Conclusions:There is a compelling need for more systematic studies examining patients with psychiatric/neurological disorders with larger samples and harmonised tDCS protocols. More studies will potentially help us to understand the tDCS mechanism of action pertinent to neuro-metabolite levels modulation. Further, studies should be conducted in psychiatric patients to understand the neurological changes in this population and potentially unravel the neuro-metabolite × tDCS interaction effect that can be translated into individualised treatment. |
| Databáze: | OpenAIRE |
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