The ADP-ribosylation factor-like small GTPase FgArl1 participates in growth, pathogenicity and DON production in Fusarium graminearum
| Autor: | Yao Wang, Zuodong Wang, Yixiao Wang, Chenyu Wang, Hansong Dong, Liyuan Zhang, Lei Chen, Shenshen Zou, Yuancun Liang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Fusarium ADP ribosylation factor Mutant Biology 01 natural sciences Fungal Proteins 03 medical and health sciences symbols.namesake Genetics Humans Small GTPase Pathogen Ecology Evolution Behavior and Systematics Monomeric GTP-Binding Proteins Plant Diseases 030304 developmental biology 0303 health sciences Virulence ADP-Ribosylation Factors food and beverages Golgi apparatus biology.organism_classification Yeast Cell biology Vesicular transport protein Infectious Diseases symbols Trichothecenes 010606 plant biology & botany |
| Zdroj: | Fungal Biology. 124:969-980 |
| ISSN: | 1878-6146 |
| Popis: | Fusarium graminearum is the main pathogen of Fusarium head blight (FHB) in wheat and related species, which causes serious production decreases and economic losses and produces toxins such as deoxynivalenol (DON), which endangers the health of humans and livestock. Vesicle transport is a basic physiological process required for cell survival in eukaryotes. Many regulators of vesicle transport are reported to be involved in the pathogenicity of fungi. In yeast and mammalian cells, the ADP-ribosylation factor-like small GTPase Arl1 and its orthologs are involved in regulating vesicular trafficking, cytoskeletal reorganization and other significant biological processes. However, the role of Arl1 in F. graminearum is not well understood. In this study, we characterized the Arl1-homologous protein FgArl1 in F. graminearum and showed that FgArl1 is located in the trans-Golgi apparatus. The deletion of FgARL1 resulted in a significant decrease in vegetative growth and pathogenicity. Further analyses of the ΔFgarl1 mutant revealed defects in the production of DON. Taken together, these results indicate that FgArl1 is important in the development and pathogenicity of F. graminearum. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect