Translational approach to apathy‐like behavior in mice: From the practical point of view
| Autor: | Kenji F. Tanaka, Takuya Hamaguchi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Striatal dopamine
animal structures Ventrolateral striatum Apathy Receptor type Optogenetics Medium spiny neuron Translational Research Biomedical Mice 03 medical and health sciences 0302 clinical medicine medicine Animals Loss function Cell specific Behavior Animal General Neuroscience General Medicine 030227 psychiatry Psychiatry and Mental health Neurology sense organs Neurology (clinical) medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery Behavioral Research |
| Zdroj: | Psychiatry and Clinical Neurosciences. 73:685-689 |
| ISSN: | 1440-1819 1323-1316 |
| Popis: | Apathy is a pervasive clinical phenomenon that deserves more attention at the translational and pre-clinical levels. To study apathy-like behavior in mice, we relied on an operational definition of apathy: the quantitative reduction of voluntary, goal-directed behaviors. We recently found that the chronic loss of function of a specific cell type (striatal dopamine receptor type 2-expressing medium spiny neurons, D2-MSN) in a restricted region (the ventrolateral striatum, VLS) was sufficient to induce apathy-like behavior in a food-seeking operant task. We further showed that VLS D2-MSN are activated at the preparatory period, and that optogenetic inhibition of VLS D2-MSN during that period resulted in transient decreases in instrumental motivation, strengthening the hypothesis that VLS D2-MSN mediate apathy-like behavior in mice. Mice bearing VLS D2-MSN dysfunction can thus be regarded as an apathy model for future translational studies. |
| Databáze: | OpenAIRE |
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