Chenopodin as an anti-inflammatory compound
| Autor: | Renes R. Machado, Flávia Cristina Policarpo Tonelli, Helon Guimarães Cordeiro, Márcio M. Coelho, Ivo S.F. Melo, José Antônio da Silva, Adriana M. Godin, Tamires C. Matsui, Dávia Guimarães Pompeu, Paulo Afonso Granjeiro, Felipe F. Rodrigues |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Globulin
medicine.drug_class Anti-Inflammatory Agents Inflammation Plant Science Carrageenan Biochemistry Chenopodium quinoa Anti-inflammatory Homology (biology) Analytical Chemistry chemistry.chemical_compound Mice In vivo medicine Animals Edema Humans biology Chemistry Organic Chemistry Molecular biology biology.protein medicine.symptom Paw edema |
| Zdroj: | Natural product research. 36(17) |
| ISSN: | 1478-6427 |
| Popis: | Chenopodin is an 11S-type globulin purified from Chenopodium quinoa seeds, which can bind carbohydrates and hemagglutinating human erythrocytes. The present study aimed to evaluate the N-terminal structure of the heterodimeric Chenopodin and its effects in models of inflammation. Chenopodin presented two subunits on its structure and has N-terminal homology with other Chenopodin in 92%. Chenopodin decreased paw edema and neutrophil recruitment induced by carrageenan in mice. Concluding, we demonstrated that Chenopodin exhibits in vivo anti-inflammatory activity. |
| Databáze: | OpenAIRE |
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