Post-translational modification-derived products are associated with frailty status in elderly subjects
| Autor: | Jean-Luc Novella, Rachid Mahmoudi, Yacine Jaidi, Sarah Badr, Stéphane Jaisson, Philippe Gillery, Laurie-Anne Bertholon |
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| Přispěvatelé: | Hôpital de Reims - Service de neuro-gériatrie, Hôpital de Reims, Matrice extracellulaire et dynamique cellulaire - UMR 7369 (MEDyC), SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS), Fluides, automatique, systèmes thermiques (FAST), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Reims (CHU Reims), Université de Reims Champagne-Ardenne (URCA) |
| Rok vydání: | 2019 |
| Předmět: |
Glycation End Products
Advanced Male 0301 basic medicine Albumin concentrations medicine.medical_specialty Multivariate analysis Frail Elderly Clinical Biochemistry Thyrotropin Renal function 030204 cardiovascular system & hematology Logistic regression Hemoglobins 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Albumins Internal medicine medicine Humans [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Frail elderly Pentosidine ComputingMilieux_MISCELLANEOUS Aged Aged 80 and over Homocitrulline business.industry Biochemistry (medical) General Medicine 3. Good health C-Reactive Protein 030104 developmental biology chemistry Creatinine Posttranslational modification Female business Protein Processing Post-Translational Blood Chemical Analysis Glomerular Filtration Rate |
| Zdroj: | Clinical Chemistry and Laboratory Medicine Clinical Chemistry and Laboratory Medicine, De Gruyter, 2019, 57 (8), pp.1153-1161. ⟨10.1515/cclm-2018-1322⟩ |
| ISSN: | 1437-4331 1434-6621 |
| DOI: | 10.1515/cclm-2018-1322 |
| Popis: | Background Identifying frail elderly subjects is of paramount importance in order to conduct a tailored care. The characterization of frailty status is currently based on the collection of clinical data and on the use of various tools such as Fried’s criteria, which constitutes a difficult and time-consuming process. Up to now, no biological markers have been described as reliable tools for frailty characterization. We tested the hypothesis that a link between frailty and protein molecular aging existed. This study aimed therefore at determining whether post-translational modification derived products (PTMDPs), recognized as biomarkers of protein aging, were associated with frailty status in elderly subjects. Methods Frailty status was determined according to Fried’s criteria in 250 elderly patients (>65 years old) hospitalized in a short-term care unit. Serum concentrations of protein-bound PTMDPs, including carboxymethyllysine (CML), pentosidine, methylglyoxal-hydroimidazolone-1 and homocitrulline (HCit), were determined by liquid chromatography coupled with tandem mass spectrometry, and tissue content of advanced glycation end-products was assessed by skin autofluorescence (SAF) measurement. Associations between PTMDPs and frailty status were analyzed using logistic regression models. Results Frail patients had significantly (p Conclusions HCit and SAF are significantly associated with frailty status in elderly subjects. This study suggests that PTMDPs constitute promising biomarkers for identifying frail patients and guiding personalized patient care. |
| Databáze: | OpenAIRE |
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