miR-142-3p as a novel biomarker for predicting poor prognosis in renal cell carcinoma patients after surgery
| Autor: | Fangting Zhang, Xiqi Peng, Weijie Xu, Yongqing Lai, Xiang Pan, Liwen Zhao, Jinling Xu, Hang Li, Xin Guan, Kaihao Liu, Chunduo Zhang |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Oncology Cancer Research medicine.medical_specialty Poor prognosis Clinical Biochemistry Total rna medicine.disease_cause Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Renal cell carcinoma Internal medicine microRNA Biomarkers Tumor medicine Humans Prognostic biomarker Carcinoma Renal Cell business.industry Middle Aged Prognosis medicine.disease Kidney Neoplasms MicroRNAs 030104 developmental biology Mir 142 3p 030220 oncology & carcinogenesis Biomarker (medicine) Female business Carcinogenesis |
| Zdroj: | The International Journal of Biological Markers. 34:302-308 |
| ISSN: | 1724-6008 |
| DOI: | 10.1177/1724600819866456 |
| Popis: | Background: miR-142-3p has proved to be involved in tumorigenesis and the development of renal cell carcinoma. The present study aimed to explore the prognostic value of miR-142-3p. Methods: Total RNA was extracted from renal cell carcinoma specimens and the expression level of miR-142-3p was measured. Pearson Chi-square test, Kaplan–Meier analysis, as well as univariate and multivariate regression analysis were performed to determine the correlation between miR-142-3p and the prognosis of renal cell carcinoma patients. Receiver operating characteristic curves were constructed to evaluate the predictive efficiency of miR-142-3p for the prognosis of renal cell carcinoma patients. Data from The Cancer Genome Atlas (TCGA) were utilized to validate our findings. Results: Our results demonstrated that upregulation of miR-142-3p was correlated with shorter overall survival (P=0.002) and was, in the meantime, an independent prognostic factor for renal cell carcinoma patients (P=0.002). The receiver operating characteristic curve combining miR-142-3p expression with tumor stage showed an area under the curve of 0.633 (95% confidence interval 0.563, 0.702). The result of TCGA data was consistent with our findings. Conclusions: Our results suggest miR-142-3p expression is correlated with poor prognosis of renal cell carcinoma patients and may serve as a prognostic biomarker in the future. |
| Databáze: | OpenAIRE |
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