Real Time Intraoperative Functional Brain Mapping Based on RGB Imaging
| Autor: | C. Caredda, Michaël Sdika, Jacques Guyotat, Raphaël Sablong, Bruno Montcel, Laurent Mahieu-Williame |
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| Přispěvatelé: | RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Plateforme d'Imagerie Multimodale LyonTech (PILoT), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL) |
| Rok vydání: | 2021 |
| Předmět: |
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging
Computer science [SDV]Life Sciences [q-bio] 0206 medical engineering Biomedical Engineering Biophysics 02 engineering and technology Human brain 020601 biomedical engineering 030218 nuclear medicine & medical imaging 03 medical and health sciences Functional brain 0302 clinical medicine Optical imaging medicine.anatomical_structure Robustness (computer science) Cortex (anatomy) medicine White light RGB color model Neuroscience ComputingMilieux_MISCELLANEOUS Electrical brain stimulation |
| Zdroj: | Innovation and Research in BioMedical engineering Innovation and Research in BioMedical engineering, Elsevier Masson, 2020, ⟨10.1016/j.irbm.2020.04.004⟩ |
| ISSN: | 1959-0318 |
| DOI: | 10.1016/j.irbm.2020.04.004 |
| Popis: | Intraoperative optical imaging is a localization technique for the functional areas of the human brain cortex during neurosurgical procedures. However, it still lacks robustness to be used as a clinical standard. In particular new biomarkers of brain functionality with improved sensitivity and specificity are needed. We present a method for the real time identification of the activated cortical areas based on the analysis of the cortical hemodynamic using a RGB camera and a white light source. We measure the quantitative oxy and deoxy-hemoglobin concentration changes in the human brain cortex with the modified Beer-Lambert law and Monte Carlo simulations. A functional model has been implemented to define in real time a binary biomarker of the cortical activation following neuronal activation by physiological stimuli. The results show a good correlation between the computed activation maps and the brain areas localized by electrical brain stimulation. We demonstrate that a RGB camera combined with a quantitative modeling of brain hemodynamics biomarkers can evaluate in real time the functional areas during neurosurgery and serve as a tool of choice to complement electrical brain stimulation. |
| Databáze: | OpenAIRE |
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