Endothelial CYP2J2 overexpression restores the BRB via METTL3 ‐mediated ANXA1 upregulation

Autor:	Bowen Zhao, Jingqiu Huang, Xiaotong Lou, Ke Yao, Meng Ye, Qianxue Mou, Zheng Wen, Qiming Duan, Hong Zhang, Yin Zhao
Rok vydání:	2022
Předmět:	Retinal Ganglion Cells Diabetic Retinopathy Methyltransferases Cytochrome P-450 CYP2J2 Biochemistry Up-Regulation Rats Capillary Permeability Retinal Diseases Blood-Retinal Barrier Genetics Humans Animals Endothelium Molecular Biology Annexin A1 Biotechnology
Zdroj:	The FASEB Journal. 36
ISSN:	1530-6860 0892-6638
Popis:	Blood-retinal barrier (BRB) breakdown is responsible for multiple ocular diseases, such as diabetic retinopathy, age-related macular degeneration, and retinal vascular occlusive diseases. Increased vascular permeability contributes to vasogenic edema and tissue damage, with consequent adverse effects on vision. Herein, we found that endothelial CYP2J2 overexpression maintained BRB integrity after ischemia-reperfusion injury and consequently protected against retinal ganglion cell loss. Oxidative stress repressed endothelial ANXA1 expression in vivo and in vitro. CYP2J2 upregulated methyltransferase-like 3 (METTL3) expression and hence promoted ANXA1 translation via ANXA1 m
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ab1fab7b99fcd35b61c1591f25baaf https://doi.org/10.1096/fj.202201061rr Zobrazit plný text záznamu Plný text