Apathy and White Matter Integrity in Alzheimer’s Disease: A Whole Brain Analysis with Tract-Based Spatial Statistics
| Autor: | Won-Sang Jung, Hyun-Kook Lim, Chang-Uk Lee, Changtae Hahn, Wang Yeon Won, Kook Jin Ahn |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Genu of the corpus callosum Anatomy and Physiology lcsh:Medicine Audiology Corpus callosum Nerve Fibers Myelinated Diagnostic Radiology Corpus Callosum Cingulum (brain) Apathy lcsh:Science Psychiatry Aged 80 and over Brain Mapping Multidisciplinary Brain Magnetic Resonance Imaging medicine.anatomical_structure Mental Health Diffusion Tensor Imaging Neurology Medicine Female medicine.symptom Alzheimer's disease Radiology Research Article medicine.medical_specialty Splenium Neuropsychiatric Disorders Biology Neurological System White matter Alzheimer Disease Fractional anisotropy medicine Humans Aged Models Statistical lcsh:R Reproducibility of Results medicine.disease Neuroanatomy Anisotropy lcsh:Q Dementia Neuroscience |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 1, p e53493 (2013) |
| ISSN: | 1932-6203 |
| Popis: | The aim of this study was to investigate the microstructural alterations of white matter (WM) in Alzheimer's disease (AD) patients with apathy and to observe the relationships with the severity of apathy. Sixty drug-naïve subjects took part in this study (30 apathetic and 30 nonapathetic subjects with AD). The loss of integrity in WM was compared in AD patients with and without apathy through measurement of fractional anisotropy (FA) using by tract-based spatial statistics (TBSS). In addition, we explored the correlation pattern between FA values and the severity of apathy in AD patients with apathy. The apathy group had significantly reduced FA values (p(corrected) |
| Databáze: | OpenAIRE |
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