Implementation of SARS-CoV-2 monoclonal antibody infusion sites at three medical centers in the United States: Strengths and challenges assessment to inform COVID-19 pandemic and future public health emergency use
| Autor: | Anastasia S. Lambrou, John T. Redd, Miles A. Stewart, Kaitlin Rainwater-Lovett, Jonathan K. Thornhill, Lynn Hayes, Gina Smith, George M. Thorp, Christian Tomaszewski, Adolphe Edward, Natalia Elías Calles, Mark Amox, Steven Merta, Tiffany Pfundt, Victoria Callahan, Adam Tewell, Helga Scharf-Bell, Samuel Imbriale, Jeffrey D. Freeman, Michael Anderson, Robert P. Kadlec |
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| Rok vydání: | 2022 |
| Předmět: |
COVID-19 pandemic
Antibodies Vaccine Related pandemic response Clinical Research Biodefense Monoclonal Humans infusion Pandemics Lung Strategic Ecosystem SARS-CoV-2 Prevention medical countermeasure Public Health Environmental and Occupational Health COVID-19 Health Services United States Defence & Security Studies Infectious Diseases Emerging Infectious Diseases Good Health and Well Being monoclonal antibody Pneumonia & Influenza Public Health and Health Services Public Health Biotechnology |
| Zdroj: | Disaster medicine and public health preparedness. |
| ISSN: | 1938-744X |
| Popis: | Monoclonal antibody therapeutics to treat coronavirus disease (COVID-19) have been authorized by the US Food and Drug Administration under Emergency Use Authorization (EUA). Many barriers exist when deploying a novel therapeutic during an ongoing pandemic, and it is critical to assess the needs of incorporating monoclonal antibody infusions into pandemic response activities. We examined the monoclonal antibody infusion site process during the COVID-19 pandemic and conducted a descriptive analysis using data from 3 sites at medical centers in the United States supported by the National Disaster Medical System. Monoclonal antibody implementation success factors included engagement with local medical providers, therapy batch preparation, placing the infusion center in proximity to emergency services, and creating procedures resilient to EUA changes. Infusion process challenges included confirming patient severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positivity, strained staff, scheduling, and pharmacy coordination. Infusion sites are effective when integrated into pre-existing pandemic response ecosystems and can be implemented with limited staff and physical resources. |
| Databáze: | OpenAIRE |
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