Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution
Autor: | Kristin D. Lane, Xin-zhuan Su, Lu Xia, Juliana M. Sá, Thomas E. Wellems |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Microbiology (medical) Epidemiology 030231 tropical medicine Population Review Drug resistance Disease Biology Plasmodium 03 medical and health sciences 0302 clinical medicine parasitic diseases Antigenic variation medicine Artemisinin education Genetics education.field_of_study General Immunology and Microbiology Transmission (medicine) Public Health Environmental and Occupational Health medicine.disease biology.organism_classification 030104 developmental biology Infectious Diseases Malaria medicine.drug |
Zdroj: | Clin Microbiol Rev |
ISSN: | 1098-6618 0893-8512 |
Popis: | Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that continues to afflict hundreds of millions of people every year. Infections with malaria parasites can be asymptomatic, with mild or severe symptoms, or fatal, depending on many factors such as parasite virulence and host immune status. Malaria can be treated with various drugs, with artemisinin-based combination therapies (ACTs) being the first-line choice. Recent advances in genetics and genomics of malaria parasites have contributed greatly to our understanding of parasite population dynamics, transmission, drug responses, and pathogenesis. However, knowledge gaps in parasite biology and host-parasite interactions still remain. Parasites resistant to multiple antimalarial drugs have emerged, while advanced clinical trials have shown partial efficacy for one available vaccine. Here we discuss genetic and genomic studies of Plasmodium biology, host-parasite interactions, population structures, mosquito infectivity, antigenic variation, and targets for treatment and immunization. Knowledge from these studies will advance our understanding of malaria pathogenesis, epidemiology, and evolution and will support work to discover and develop new medicines and vaccines. |
Databáze: | OpenAIRE |
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