Age-dependency of cardiac and neuromuscular findings in adults with left ventricular hypertrabeculation/noncompaction
| Autor: | Katharina Bichler, Christian Wegner, Martin Gessner, Josef Finsterer, Gerhard Blazek, Claudia Stöllberger |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Heart Defects Congenital Male medicine.medical_specialty medicine.medical_treatment Cohort Studies Young Adult Age Distribution Internal medicine Diabetes mellitus medicine Palpitations Prevalence Humans Cardiac Resynchronization Therapy Devices Young adult Survival rate Aged Aged 80 and over business.industry Age Factors Neuromuscular Diseases Middle Aged medicine.disease Defibrillators Implantable Survival Rate Heart failure Ventricular assist device Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business Cohort study |
| Zdroj: | The American journal of cardiology. 115(9) |
| ISSN: | 1879-1913 |
| Popis: | Left ventricular hypertrabeculation/noncompaction (LVHT) is diagnosed in all ages and is frequently associated with neuromuscular disorders (NMDs). The aim of the study was to compare patients with LVHT depending on age at diagnosis. Included were 232 patients with LVHT (72 women, mean age 52 ± 17 years) diagnosed from 1995 to 2014 at 1 echocardiographic laboratory. In 2014, their survival was assessed. Seventy-six percent of the patients were neurologically investigated, revealing specific NMDs in 18%, unspecific NMDs in 60%, and normal findings in 22%. Forty-five patients (19%) received electronic devices: implantable cardioverter-defibrillators in 26 patients, combined with cardiac resynchronization systems (n = 14) or an antibradycardic pacemaker (n = 1); antibradycardic pacemakers (n = 8); cardiac resynchronization systems (n = 4); implantable loop recorders (n = 4); life vests (n = 2); and a left ventricular assist device as a bridge to transplantation (n = 1). During 72-month follow-up, mortality was 4.9% per year. In younger age groups, more patients were referred for syncope or palpitations, whereas in older age groups, more patients were referred for heart failure. Classic cardiovascular risk factors such as hypertension and diabetes, as well as coronary artery stenosis, were rare in the young age groups but were more prevalent in older age groups. Differences between age groups were found regarding cardiac symptoms, NMDs, electrocardiographic findings, rate of device implantation, and mortality but not in location and extension of LVHT. None of the neurologically investigated patients ≥70 years of age was neurologically normal. Prevalence of heart failure, electrocardiographic abnormalities, and mortality were highest in the oldest age group. In conclusion, LVHT must be considered as an echocardiographic diagnosis in all age groups. The morphologic pattern of LVHT is similar, whereas clinical manifestations and prognosis are variable among age groups. |
| Databáze: | OpenAIRE |
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