Radiation-Induced Antitumor Properties of Vitamin B5 (Pantothenic Acid) and its Effect on Mitomycin C Activity: Experiments In Vitro
| Autor: | Heike Schittl, Nikola Getoff |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Vitamin
Radiation-Sensitizing Agents Cancer Research Free Radicals Mitomycin Radical Antineoplastic Agents medicine.disease_cause Models Biological Pantothenic Acid chemistry.chemical_compound Pantothenic acid Escherichia coli medicine Dose-Response Relationship Drug Chemistry Mitomycin C Dose-Response Relationship Radiation Drug Synergism Biological activity General Medicine Oxygen B vitamins Oncology Biochemistry Gamma Rays Radiolysis Reactive Oxygen Species Oxidation-Reduction |
| Zdroj: | Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics. 16:389-394 |
| ISSN: | 0965-0407 |
| DOI: | 10.3727/000000006783980919 |
| Popis: | Vitamin B5 (pantothenic acid) shows a strongly pronounced antitumor effect under the influence of ionizing radiation. In the frame of experiments in vitro (model: Escherichia coli bacteria, AB1157) performed under the exact knowledge of concentration and kind of the free radicals acting in the various aqueous media (pH 7.4) the following was established: (i) vitamin B5 possesses a very intense antitumor property, (ii) it exerts a strong synergistic effect on mitomycin C (MMC), (iii) the oxidizing species (OH*, O2*-) appears to be most important in the initiation of the observed effect. The generated radiolytic products from vitamin B5 very likely also play an important role in this respect. |
| Databáze: | OpenAIRE |
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