Goji berry (Lycium barbarum L.) juice reduces lifespan and premature aging of Caenorhabditis elegans: Is it safe to consume it?
| Autor: | Cristiane de Freitas Rodrigues, Cristiane Casagrande Denardin, Marcell Valandro Soares, Tatiana Emanuelli, Sabrina Somacal, Paula Rossini Augusti, Aryele Pinto Izaguirry, Jean Ramos Boldori, Francielli Weber Santos Cibin |
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| Rok vydání: | 2021 |
| Předmět: |
Premature aging
Antioxidant 030309 nutrition & dietetics medicine.medical_treatment Longevity medicine.disease_cause 03 medical and health sciences 0404 agricultural biotechnology food medicine Animals Food science Caenorhabditis elegans Caenorhabditis elegans Proteins Carotenoid chemistry.chemical_classification 0303 health sciences Reactive oxygen species biology Goji berry Aging Premature 04 agricultural and veterinary sciences Lycium biology.organism_classification 040401 food science food.food chemistry Toxicity Oxidative stress Food Science |
| Zdroj: | Food Research International. 144:110297 |
| ISSN: | 0963-9969 |
| DOI: | 10.1016/j.foodres.2021.110297 |
| Popis: | Goji berry fruit is considered a healthy food. However, studies on its effects on aging and safety are rare. This study is the first to evaluate the effects of goji berry juice (GBJ) on oxidative stress, metabolic markers, and lifespan of Caenorhabditis elegans. GBJ caused toxicity, reduced the lifespan of C. elegans by 50%, and increased the reactive oxygen species (ROS) production by 45–50% at all tested concentrations (1–20 mg/µL) of GBJ. Moreover, the highest concentration of GBJ increased lipid peroxidation by 80% and altered the antioxidant enzymes. These effects could be attributed to a pro-oxidant effect induced by GBJ polyphenols and carotenoids. Moreover, GBJ increased lipofuscin, glucose levels, number of apoptotic bodies, and lipase activity. The use of mutant strains demonstrated that these effects observed in the worms treated with GBJ were not associated with the Daf-16/FOXO or SKN-1 pathways. Our findings revealed that GBJ (mainly the highest concentration) exerted toxic effects and promoted premature aging in C. elegans. Therefore, its consumption should be carefully considered until further studies in mammals are conducted. |
| Databáze: | OpenAIRE |
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