Alendronate Inhibits Bone Resorption at the Bone-screw Interface
| Autor: | Yoshiaki Azuma, Nobuyuki Shimizu, Yasuo Uchiyama, Takanobu Nakase, Hideki Yoshikawa, Takahiro Miyaji |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
musculoskeletal diseases External fixator External Fixators medicine.medical_treatment Acid Phosphatase Bone Screws Cathepsin K Dentistry Bone resorption medicine Animals Orthopedics and Sports Medicine Femur Bone Resorption Rats Wistar Inhibitory effect Alendronate Tartrate-Resistant Acid Phosphatase business.industry Alendronic acid General Medicine Bisphosphonate equipment and supplies musculoskeletal system Cathepsins Prosthesis Failure Rats Isoenzymes Bone screws Disease Models Animal surgical procedures operative Systemic administration Surgery business medicine.drug |
| Zdroj: | Clinical Orthopaedics & Related Research. 430:195-201 |
| ISSN: | 0009-921X |
| DOI: | 10.1097/01.blo.0000137553.91189.67 |
| Popis: | In the current study, we investigated whether the systemic administration of alendronate, a third-generation bisphosphonate, suppressed the loosening of screws at the bone-screw interface. We systemically administered alendronate to rats fitted with external fixators. External fixators with two half pins were applied to the right femurs of rats, and alendronate was administrated once a week during a 5-week postoperative period. Radiographic, histologic, and immuno-histochemical findings subsequently were analyzed. Treatment with alendronate reduced the width of the fibrous loosening membrane and the number of osteoclasts at the bone-screw interface. These findings indicate that systemic treatment with alendronate exerts an inhibitory effect on local bone resorption at the bone-screw interface. |
| Databáze: | OpenAIRE |
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