The treatment of HIV associated thrombocytopenia in haemophiliacs
| Autor: | Christine A. Lee, Seng G. Lim, Peter B. A. Kernoff |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
medicine.medical_specialty Pediatrics Adolescent Prednisolone medicine.medical_treatment Splenectomy HIV Infections Hemophilia A Haemophilia Asymptomatic Zidovudine Acquired immunodeficiency syndrome (AIDS) medicine Coagulopathy Humans Child Infusions Intravenous Retrospective Studies Acquired Immunodeficiency Syndrome business.industry Hematology medicine.disease Thrombocytopenia Surgery Immunoglobulin G Interferons medicine.symptom business Complication medicine.drug |
| Zdroj: | Clinical & Laboratory Haematology. 12:237-245 |
| ISSN: | 0141-9854 |
| DOI: | 10.1111/j.1365-2257.1990.tb00033.x |
| Popis: | Summary HIV associated thrombocytopenia occurs in 5–10% of asymptomatic individuals, and 25–45% of people with AIDS. A variety of treatments are available but the inherited bleeding disorder in addition to the thrombocytopenia makes management in haemophiliacs a special problem. The management of this double coagulopathy is described in seven patients. IV gammaglobulin and steroids were useful only in the short term; zidovudine produced a good response, could be taken orally, had anti-HIV activity and was well tolerated in asymptomatic HIV positive patients. Interferon was an alternative when zidovudine was ineffective or produced intolerable side-effects. Splenectomy was considered only after failure of other treatments because of the increased risks of bleeding. |
| Databáze: | OpenAIRE |
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