Evaluation of Mast Cell Density in the Tumor Microenvironment in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma
| Autor: | Caroline Brandi Schlaepfer Sales, Renata Oliveira de Souza, Eduardo Antônio Gonçalves Ramos, Ludmila de Faro Valverde, Rebeca C.M. Dantas, Letícia Palmeira Sousa, Clarissa Araújo Gurgel Rocha, Jean Nunes dos Santos, Manuela Torres Andion Vidal |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Oncology
Epithelial dysplasia medicine.medical_specialty Pathology Histology Cellular differentiation Cell Count Tryptase Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Internal medicine Biomarkers Tumor Tumor Microenvironment Carcinoma medicine Humans Mast Cells Oral mucosa Tumor microenvironment biology business.industry Mouth Mucosa nutritional and metabolic diseases Cell Differentiation 030206 dentistry Prognosis medicine.disease Mast cell Immunohistochemistry eye diseases stomatognathic diseases Medical Laboratory Technology medicine.anatomical_structure 030220 oncology & carcinogenesis Carcinoma Squamous Cell biology.protein Mouth Neoplasms business |
| Zdroj: | Applied Immunohistochemistry & Molecular Morphology. 25:e83-e88 |
| ISSN: | 1541-2016 |
| Popis: | The objective of this study was to compare mast cell density (MCD) in oral epithelial dysplasias (OED) and oral squamous cell carcinoma (OSCC) and determine its correlation with clinical and histopathologic parameters and the degree of tumor differentiation. Thirty OSCC samples, 14 OED samples, and 4 non-neoplastic oral mucosa samples were analyzed by immunohistochemistry to determine MCD based on the expression of MC tryptase. In addition, MCs were categorized morphologically into degranulated and granulated cells. MCD was significantly higher in OSCC lesions with a greater degree of differentiation (P=0.04). No significant difference in MCD was detected between mild and moderate OED samples (P=0.09). Our findings indicate that MCs are present in the tumor microenvironment and may be associated with a better prognosis. |
| Databáze: | OpenAIRE |
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