Fungal sensitization and positive fungal culture from sputum in children with asthma are associated with reduced lung function and acute asthma attacks respectively
| Autor: | J. Satchwell, Kathryn G Welsh, Catherine H. Pashley, Erol A. Gaillard, Karl Holden, W Monteiro, Andrew J. Wardlaw |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Vital Capacity Penicillium chrysogenum Immunoglobulin E Severity of Illness Index 0302 clinical medicine immune system diseases Forced Expiratory Volume Candida albicans Immunology and Allergy Child Sensitization Dander biology medicine.diagnostic_test Alternaria Environmental exposure medicine.anatomical_structure Child Preschool Disease Progression Pollen Female medicine.symptom Cladosporium Adolescent Immunology Poaceae Sputum culture 03 medical and health sciences FEV1/FVC ratio medicine Animals Humans Antigens Dermatophagoides Skin Tests Asthma business.industry Aspergillus fumigatus Sputum medicine.disease respiratory tract diseases 030104 developmental biology 030228 respiratory system Acute severe asthma biology.protein business |
| Zdroj: | Clinical & Experimental Allergy. 51:790-800 |
| ISSN: | 1365-2222 0954-7894 |
| DOI: | 10.1111/cea.13799 |
| Popis: | BACKGROUND Sensitization to thermotolerant fungi, including filamentous fungi and Candida albicans, is associated with poor lung function in adults with severe asthma. Data in children are lacking. Environmental exposure to fungi is linked with acute severe asthma attacks, but there are few studies reporting the presence of fungi in the airways during asthma attacks. METHODS We investigated the association between fungal sensitization and/or positive fungal sputum culture and markers of asthma severity in children with chronic and acute asthma. Sensitization was determined using serum-specific IgE and skin prick testing against a panel of five fungi. Fungal culture was focused towards detection of filamentous fungi from sputum samples. RESULTS We obtained sensitization data and/or sputum from 175 children: 99 with chronic asthma, 39 with acute asthma and 37 controls. 34.1% of children with chronic asthma were sensitized to thermotolerant fungi compared with no children without asthma (p = |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text