Diaphragm: a vital respiratory muscle in mammals
| Autor: | Dilayla Kelly de Abreu, Bruno Machado Bertassoli, Thais Borges Lessa, Carlos Eduardo Ambrósio |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Duchenne muscular dystrophy Diaphragm Extracellular matrix 03 medical and health sciences 0302 clinical medicine Degenerative disease Species Specificity medicine Respiratory muscle Animals Humans Respiratory function biology business.industry General Medicine Anatomy musculoskeletal system medicine.disease Diaphragm (structural system) 030104 developmental biology Respiratory Mechanics biology.protein medicine.symptom MAMÍFEROS Dystrophin business 030217 neurology & neurosurgery Developmental Biology Muscle contraction |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | The diaphragm is a respiratory muscle that is primarily responsible for the respiratory function in normal individuals. In mammals, the diaphragm muscle has been studied from the early days of zoology, comparative and experimental anatomy, physiology, medicine, physics, and philosophy. However, even with these early advances in knowledge pertaining to the diaphragm, comprehensive morphological data on the diaphragm are still incomplete. In this review, we summarize the beginnings of the morphological description of the diaphragm, and we describe the current status of the known morphological and embryological features. In addition, we correlate how the impairment of the diaphragm muscle in Duchenne muscular dystrophy (DMD) can lead to patient deaths. DMD is the most common X-linked muscle degenerative disease and is caused by a lack of dystrophin protein. Dystrophin is an important muscle protein that links the cellular cytoskeleton with the extracellular matrix. In the absence of dystrophin, the muscle becomes susceptible to damage during muscle contraction. This review allows researchers to obtain an overview of the diaphragm, transcending the morphological data from animals described in conventional literature. |
| Databáze: | OpenAIRE |
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