Cilostazol suppresses intimal formation in dog grafted veins with reduction of angiotensin II-forming enzymes
| Autor: | Mizuo Miyazaki, Denan Jin, Masato Sakaguchi, Atsushi Yuda, Shinji Takai, Kazuyoshi Kirimura, Masayoshi Nishimoto |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Vasodilator Agents Tetrazoles In Vitro Techniques Peptidyl-Dipeptidase A Chymases Dogs Restenosis Internal medicine Renin–angiotensin system medicine Animals Vein Pharmacology Neovascularization Pathologic biology business.industry Angiotensin II Serine Endopeptidases Fissipedia Phosphodiesterase medicine.disease biology.organism_classification Cilostazol Transplantation Endocrinology medicine.anatomical_structure cardiovascular system Blood Vessels business medicine.drug |
| Zdroj: | European Journal of Pharmacology. 411:301-304 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/s0014-2999(00)00864-5 |
| Popis: | Cilostazol prevents neointimal formation, but its mechanism has remained unclear. We investigated whether intimal formation in dog grafted veins is suppressed by cilostazol, and studied the effect of cilostazol on angiotensin II-forming enzymes. The external jugular vein was grafted to the carotid artery, and cilostazol (60 mg/kg/day) was administered orally. By 28 days after the surgery, the intimal cross-sectional area of the grafted vein was reduced to 16.7% by treatment of cilostazol, and the activities of angiotensin II-forming enzymes were suppressed significantly. The inhibitory effect of cilostazol in intimal formation may be dependent on inhibition of angiotensin II-forming enzymes. |
| Databáze: | OpenAIRE |
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