Effect of thalidomide in patients with chronic heart failure
| Autor: | Rita Skårdal, Lars Gullestad, Arne Yndestad, Stig S. Frøland, Anne Grete Semb, Even Holt, Pål Aukrust, Thor Ueland |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Heart disease medicine.medical_treatment Sedation Pilot Projects Internal medicine medicine Humans Hypnotics and Sedatives In patient cardiovascular diseases Aged Heart Failure Chemotherapy Ejection fraction Tumor Necrosis Factor-alpha business.industry Stroke Volume medicine.disease Thalidomide Surgery Heart failure cardiovascular system Cardiology Female Tumor necrosis factor alpha medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers Immunosuppressive Agents medicine.drug |
| Zdroj: | American Heart Journal. 144:847-850 |
| ISSN: | 0002-8703 |
| Popis: | Congestive heart failure (CHF) is characterized by enhanced immune activation, which possibly plays a pathogenic role in this disorder. We therefore examined whether immunomodulation with thalidomide could improve cardiac performance in patients with CHF.Nine patients with chronic symptomatic CHF and left ventricular ejection fraction (LVEF)40%, who were receiving "optimal" conventional cardiovascular treatment, were given 200 mg thalidomide daily in an open design for a period of 6 weeks. Tumor necrosis factor (TNF)-alpha and LVEF were measured at baseline and on completion of the study.Two patients withdrew because of side effects. Sedation was common and required dose reduction in 6 of 7 patients completing the study. Plasma levels of TNF-alpha were elevated at baseline compared with levels in healthy control patients, but decreased significantly from 33.9 +/- 10.1 pg/mL to 19.3 +/- 6.1 pg/mL during therapy (P.05). LVEF increased in all patients from 26% +/- 9% to 34% +/- 10% at the end of the observation period (P.05).In this pilot study, therapy with thalidomide in patients with CHF resulted in decreased TNF-alpha levels and increased cardiac performance. Although few patients were included, our results suggest that thalidomide should be further investigated as an immunomodulating agent in CHF. |
| Databáze: | OpenAIRE |
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