Denitrative hydroxylation of unactivated nitroarenes

Autor:	Lee Duff, Harry Meakin, Adam Richardson, Andrew Greener, George Smith, Ivan Ocaña, Victor Chechik, Michael James
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	denitrative functionalisation Organic Chemistry nitroarenes radical anion General Chemistry Catalysis S 1 hydroxylation
Zdroj:	Duff, L, Meakin, H, Richardson, A, Greener, A J, Smith, G W A, Ocaña, I, Chechik, V & James, M J 2023, ' Denitrative hydroxylation of unactivated nitroarenes ', Chemistry – A European Journal . https://doi.org/10.1002/chem.202203807
Popis:	A one-step method for the conversion of nitroarenes into phenols under operationally simple, transition-metal-free conditions is described. This denitrative functionalisation protocol provides a concise and economical alternative to conventional three-step synthetic sequences. Experimental and computational studies suggest that unactivated nitroarenes may be substituted via an electron-catalysed radical-nucleophilic substitution (SRN1) chain mechanism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7998eafe6667c4a2d1341a3e3ec1a5ac https://doi.org/10.1002/chem.202203807 Zobrazit plný text záznamu