Stressful life events and affective disorders inhibit pulsatile LH secretion in hypothalamic amenorrhea

Autor: Loredana Fioroni, Maurizio Fava, Andrea R. Genazzani, Alessandro D. Genazzani, Fabio Facchinetti
Rok vydání: 1993
Předmět:
Adult
medicine.medical_specialty
medicine.drug_class
Menstrual disorder
Endocrinology
Diabetes and Metabolism
Hypothalamus
Pulsatile flow
Adult
Amenorrhea
physiopathology/psychology
Anxiety Disorders
physiopathology/psychology
Depressive Disorder
physiopathology/psychology
Female
Gonadal Steroid Hormones
blood
Humans
Hypothalamus
physiopathology
Life Change Events
Luteinizing Hormone
secretion
Mood Disorders
physiopathology/psychology
Pulsatile Flow
physiology
Life Change Events
Endocrinology
blood
Internal medicine
medicine
Humans
Psychogenic disease
Gonadal Steroid Hormones
Amenorrhea
physiopathology/psychology
Biological Psychiatry
Depressive Disorder
Mood Disorders
Endocrine and Autonomic Systems
Luteinizing Hormone
medicine.disease
Anxiety Disorders
secretion
Psychiatry and Mental health
Pulsatile Flow
Anxiety
Female
physiopathology
Gonadotropin
medicine.symptom
Psychology
Body mass index
Blood sampling
Zdroj: Psychoneuroendocrinology. 18:397-404
ISSN: 0306-4530
DOI: 10.1016/0306-4530(93)90014-c
Popis: The aim of this study was to evaluate relationships between emotional state and hypothalamic activity in patients with hypothalamic secondary amenorrhea. Sixty-seven normal weight patients with hypothalamic amenorrhea were submitted to concomitant psychological and LH pulsatility evaluation. Structured clinical interview for anxiety and depressive disorders (DSM III-R) as well as life events investigations (Paykel test) were performed. LH pulses (blood sampling every 10 min for 4 hr) were analyzed through DETECT program and Instantaneous Secretory Rate were computed. Twenty-one patients reporting life events associated to the onset of amenorrhea had LH pulse frequency (2.28 ± 1.10 pulses/4 hr) lower than those without life events (3.40 ± 1.46 p = .007). LH pulses amplitude was lower in patients meeting a DSM III-R (21 cases: 1.22 ± 0.96 mIU/ml) diagnosis than in those without (1.99 ± 1.20 p = .04) diagnosis. Plasma estradiol and FSH levels as well as duration of amenorrhea and Body Mass Index were similar among groups. It is concluded that psychogenic factors (namely the presence of life events related to the onset of menstrual disorder) are associated with significant and specific changes of hypothalamic activity which could be involved in determining hypogonadism.
Databáze: OpenAIRE
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