Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy
| Autor: | Christian Rolfo, José A. Lorente, Massimo Cristofanilli, Umberto Malapelle, Luis Paz-Ares, Eduardo Vilar, Alessandro Russo, Juan Jose Diaz Mochon, María del Carmen Garrido-Navas, Andrés F. Cardona, María José Serrano, Patrick Pauwels, Luis E. Raez, Antonio J. Ruiz-Rodriguez, Ignacio Gil-Bazo |
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| Přispěvatelé: | Serrano, M. J., Garrido-Navas, M. C., Mochon, J. J. D., Cristofanilli, M., Gil-Bazo, I., Pauwels, P., Malapelle, U., Russo, A., Lorente, J. A., Ruiz-Rodriguez, A. J., Paz-Ares, L. G., Vilar, E., Raez, L. E., Cardona, A. F., Rolfo, C., International Society of Liquid Biopsy |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty 03 medical and health sciences 0302 clinical medicine Circulating tumor cell Neoplasms Internal medicine medicine Humans Precision Medicine Liquid biopsy Prospective cohort study Biomedicine business.industry Liquid Biopsy Cancer medicine.disease Circulating biomarkers 030104 developmental biology 030220 oncology & carcinogenesis Cancer management Human medicine Interception business |
| Zdroj: | Cancer discovery |
| ISSN: | 2159-8290 2159-8274 |
| Popis: | Despite major therapeutic progress, most advanced solid tumors are still incurable. Cancer interception is the active way to combat cancer onset, and development of this approach within high-risk populations seems a logical first step. Until now, strategies for the identification of high-risk subjects have been based on low-sensitivity and low-specificity assays. However, new liquid biopsy assays, “the Rosetta Stone of the new biomedicine era,” with the ability to identify circulating biomarkers with unprecedented sensitivity, promise to revolutionize cancer management. This review focuses on novel liquid biopsy approaches and the applications to cancer interception. Cancer interception involves the identification of biomarkers associated with developing cancer, and includes genetic and epigenetic alterations, as well as circulating tumor cells and circulating epithelial cells in individuals at risk, and the implementation of therapeutic strategies to prevent the beginning of cancer and to stop its development. Large prospective studies are needed to confirm the potential role of liquid biopsy for early detection of precancer lesions and tumors. |
| Databáze: | OpenAIRE |
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