Exposure to exogenous enkephalins disrupts reproductive development in the Eastern lubber grasshopper, Romalea microptera (Insecta: Orthoptera)
| Autor: | Sandeep Kumar, Laurence von Kalm, Hojun Song, David W. Borst, Purnachandra Nagaraju Ganji |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Anatomy and Physiology Enkephalin Organogenesis Developmental Signaling lcsh:Medicine (+)-Naloxone Insect Biochemistry 0302 clinical medicine Molecular Cell Biology Testis polycyclic compounds lcsh:Science Animal Management media_common 0303 health sciences Multidisciplinary biology Naloxone Reproduction digestive oral and skin physiology Insect physiology Agriculture Enkephalins Signaling in Selected Disciplines medicine.anatomical_structure Female Development of the gonads hormones hormone substitutes and hormone antagonists Research Article Signal Transduction Enkephalin Leucine medicine.medical_specialty endocrine system Orthoptera Enkephalin Methionine media_common.quotation_subject Ovary Grasshoppers 03 medical and health sciences Internal medicine medicine Animals Biology 030304 developmental biology Lubber grasshopper lcsh:R biology.organism_classification Endocrinology nervous system Oocytes lcsh:Q Organism Development Zoology Entomology 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | PLoS ONE, Vol 7, Iss 11, p e51126 (2012) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Enkephalins play a major role in reproductive physiology in crustaceans; however their role in reproductive development in insects is largely unknown. We investigated the effect of exposure to exogenous leucine-enkephalin (Leu-Enk), methionine-enkephalin (Met-Enk), and the opioid antagonist naloxone on gonad development in the Eastern lubber grasshopper, Romalea microptera. Injection of either Leu-Enk or naloxone alone significantly increased the testicular index and testicular follicular diameter in males, and the ovarian index, oocyte length, and oocyte diameter in females. In contrast, injection of Met-Enk inhibited all measures of reproductive development in both sexes. Surprisingly, co-injection of naloxone with either enkephalin enhanced the effect associated with administration of the enkephalin alone. This study clearly demonstrates the ability of enkephalins to disrupt insect sexual development and also suggests the existence of conserved enkephaline-dependent regulatory mechanisms in insects and crustaceans. |
| Databáze: | OpenAIRE |
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