Efficacy of Artemether-Lumefantrine in Area of High Malaria Endemicity in India and Its Correlation with Blood Concentration of Lumefantrine
| Autor: | Yngve Bergqvist, Suman Sundar Mohanty, Pascal Ringwald, Neena Valecha, Surya K. Sharma, Prajesh K. Tyagi, Prakriti Srivastava |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Artemether/lumefantrine chemistry.chemical_compound Medicine Artemether Malaria Falciparum Child Whole blood biology Articles Middle Aged Artemisinins Drug Combinations Treatment Outcome Infectious Diseases Ethanolamines Child Preschool Drug Therapy Combination Female medicine.drug Adult medicine.medical_specialty Adolescent Plasmodium falciparum India Lumefantrine Antimalarials Young Adult Pharmacotherapy Virology Internal medicine parasitic diseases Humans Aged Fluorenes business.industry Artemether Lumefantrine Drug Combination Infant medicine.disease biology.organism_classification Clinical trial chemistry Immunology Patient Compliance Parasitology business Malaria Follow-Up Studies |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 86:395-397 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.2012.11-0182 |
| Popis: | This study was conducted to correlate blood concentrations of lumefantrine with treatment outcome for patients with Plasmodium falciparum malaria when the drug was given without specific instructions for administration with food. Patients with P. falciparum malaria in the highly endemic state of Orissa, India, were enrolled during 2008 and followed-up for 28 days after admistration of artemether-lumefantrine for three days according to a World Health Organization protocol. Drug concentration in whole blood was determined by using blood spots placed on filter paper on day 7. The technology is suitable for field studies. One hundred percent of the patients had an adequate clinical and parasitological response. These results confirm the efficacy of artemether-lumefantrine in persons from poor tribal communities when given without specific instructions regarding co-administration with food, despite high inter-individual variability in blood concentrations of lumefantrine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|