Peculiarities of heart rhythm variability in narcotized and immobilized wakeful rats during blockade of calcium channels
| Autor: | M. M. Fateev, M. V. Grigor’eva, F. A. Kouzmin |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Cinnarizine Nifedipine Autonomic Nervous System General Biochemistry Genetics and Molecular Biology Electrocardiography Immobilization Heart Rate Internal medicine Heart rate medicine Heart rate variability Animals medicine.diagnostic_test Voltage-dependent calcium channel Chemistry General Medicine Calcium Channel Blockers Rats Autonomic nervous system Endocrinology Verapamil medicine.drug |
| Zdroj: | Bulletin of experimental biology and medicine. 153(5) |
| ISSN: | 1573-8221 |
| Popis: | In narcotized rats, verapamil and cinnarizine modifi ed some heart rate variability (HRV) indices and heart rate (HR) indicating up-regulation of parasympathetic tone in contrast to nifedipine that elevated activity of sympathetic subdivision of ANS producing no infl uence on HR. In wakeful stressed rats, the time-domain and geometric analysis established that verapamil decreased HR and up-regulated sympathetic tone; nifedipine elevated sympathetic tone and produced no effect on HR, while cinnarizine enhanced parasympathetic tone without any effect on HR. Spectrum analysis of HRV revealed probable activation of some other neurohumoral mechanisms by the employed calcium blockers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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