Diseases of the corneal endothelium
Autor: | Lauren J. Jeang, Edgar M. Espana, Curtis E. Margo |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Corneal endothelium Stromal cell genetic structures Corneal Stroma Vision Disorders Glaucoma Article Extracellular matrix 03 medical and health sciences Cellular and Molecular Neuroscience Blister 0302 clinical medicine Ophthalmology medicine Humans Iridocorneal Endothelial Syndrome Corneal Dystrophies Hereditary business.industry Corneal Edema Endothelium Corneal Fuchs' Endothelial Dystrophy Neural crest medicine.disease eye diseases Sensory Systems Posterior polymorphous corneal dystrophy 030104 developmental biology 030221 ophthalmology & optometry Bullous keratopathy sense organs Congenital hereditary endothelial dystrophy business |
Zdroj: | Exp Eye Res |
ISSN: | 0014-4835 |
Popis: | The corneal endothelial monolayer and associated Descemet's membrane (DM) complex is a unique structure that plays an essential role in corneal function. Endothelial cells are neural crest derived cells that rest on a special extracellular matrix and play a major role in maintaining stromal hydration within a narrow physiologic range necessary for clear vision. A number of diseases affect the endothelial cells and DM complex and can impair corneal function and vision. This review addresses different human corneal endothelial diseases characterized by loss of endothelial function including: Fuchs endothelial corneal dystrophy (FECD), posterior polymorphous corneal dystrophy (PPCD), congenital hereditary endothelial dystrophy (CHED), bullous keratopathy, iridocorneal endothelial (ICE) syndrome, post-traumatic fibrous downgrowth, glaucoma and diabetes mellitus. |
Databáze: | OpenAIRE |
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