Oct-6 transcriptional factor a possible biomarker for leprosy diagnosis
| Autor: | Lina María Salazar-Peláez, Felipe Mesa-Betancourt, Nora Cardona-Castro, Héctor Serrano-Coll |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) Pathology medicine.medical_specialty Transcription Genetic Transcriptional factor Biopsy 030106 microbiology Sensitivity and Specificity 03 medical and health sciences 0302 clinical medicine Leprosy Humans Medicine 030212 general & internal medicine Mycobacterium leprae Early Growth Response Protein 2 Aged Skin integumentary system biology SOXE Transcription Factors business.industry S100 Proteins Diagnostic test General Medicine Middle Aged biology.organism_classification medicine.disease Antibodies Bacterial Immunohistochemistry Bacterial Load Cross-Sectional Studies Infectious Diseases Infectious disease (medical specialty) Immunoglobulin G Octamer Transcription Factor-6 Biomarker (medicine) Female sense organs business Biomarkers |
| Zdroj: | Diagnostic Microbiology and Infectious Disease. 99:115232 |
| ISSN: | 0732-8893 |
| Popis: | Leprosy is an infectious disease caused by Mycobacterium leprae that affects the skin and nerves. The nerve damage in leprosy may be related to alterations in transcriptional factors, such as Krox-20, Oct-6, Sox-10. Thirty skin biopsies in leprosy patients and 15 non-leprosy skin biopsies were evaluated using RT-qPCR to assess Krox-20, Oct-6, and Sox-10 and these data was related with S-100 immunohistochemistry. Changes in gene expression were observed in the skin and dermal nerves of leprosy patients in Oct-6 and Sox-10. When comparing Oct-6 with S-100 IHC as diagnostic tests for leprosy, Oct-6 showed a sensitivity of 73.3%, and specificity of 100%, while S-100 IHC showed a sensitivity of 96.6% and specificity of 100%. Our data suggest Oct-6 could be an auxiliary biomarker specific to detecting changes in dermal nerves in leprosy and thus useful to health workers and pathologists with no expertise to observe nerve injuries in leprosy. |
| Databáze: | OpenAIRE |
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