Heated IntraPEritoneal Chemotherapy (HIPEC) for Patients With Recurrent Ovarian Cancer: A Systematic Literature Review
| Autor: | Björn Lampe, Jamie Murphy, David Desai, A. Hotouras, Chetan Bhan, Paul H. Sugarbaker |
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| Rok vydání: | 2016 |
| Předmět: |
Oncology
medicine.medical_treatment Heated IntraPEritoneal Chemotherapy PSEUDOMYXOMA PERITONEI PACLITAXEL PLUS HIPEC law.invention 0302 clinical medicine Randomized controlled trial law Surgical oncology Antineoplastic Combined Chemotherapy Protocols Pseudomyxoma peritonei Prospective cohort study Peritoneal Neoplasms Ovarian Neoplasms 030219 obstetrics & reproductive medicine Obstetrics & Gynecology Obstetrics and Gynecology Prognosis Combined Modality Therapy PERITONEAL CARCINOMATOSIS 030220 oncology & carcinogenesis SURVIVAL Female Life Sciences & Biomedicine Injections Intraperitoneal medicine.medical_specialty RETROSPECTIVE COHORT CISPLATIN MORBIDITY 03 medical and health sciences Meta-Analysis as Topic Internal medicine MANAGEMENT medicine Humans SECONDARY CYTOREDUCTIVE SURGERY Oncology & Carcinogenesis Chemotherapy Science & Technology HIPEC business.industry Retrospective cohort study Hyperthermia Induced medicine.disease Surgery Recurrent ovarian cancer Neoplasm Recurrence Local Ovarian cancer business 1112 Oncology And Carcinogenesis |
| Zdroj: | International Journal of Gynecologic Cancer. 26:661-670 |
| ISSN: | 1525-1438 1048-891X |
| Popis: | BackgroundDespite advances in surgical oncology, most patients with primary ovarian cancer develop a recurrence that is associated with a poor prognosis. The aim of this review was to establish the impact of Heated IntraPEritoneal Chemotherapy (HIPEC) in the overall survival of patients with recurrent ovarian cancer.MethodsA search of PubMed/MEDLINE databases was performed in February 2015 using the terms “recurrent ovarian cancer,” “cytoreductive surgery/cytoreduction,” and “heated/hyperthermic intraperitoneal chemotherapy.” Only English articles with available abstracts assessing the impact of HIPEC in patients with recurrent ovarian cancer were examined. The primary outcome measure was overall survival, whereas secondary outcomes included disease-free survival and HIPEC-related morbidity.ResultsSixteen studies with 1168 patients were analyzed. Most studies were Level IV, with 4 studies graded as Level III and 1 Level II. Cisplatin was the main chemotherapeutic agent used, but variations were observed in the actual technique, temperature of perfusate, and duration of treatment. In patients undergoing cytoreductive surgery and HIPEC, the overall survival ranged between 26.7 and 35 months, with disease-free survival varying between 8.5 and 48 months. Heated IntraPEritoneal Chemotherapy seems to confer survival benefits to patients with recurrent disease, with a randomized controlled study reporting that the overall survival is doubled when cytoreductive surgery is compared with cytoreductive surgery and chemotherapy (13. 4 vs 26.7 months). Heated IntraPEritoneal Chemotherapy–related morbidity ranged between 13.6% and 100%, but it was mainly minor and not significantly different from that experienced by patients who only underwent cytoreduction.ConclusionsCytoreductive surgery and HIPEC seem to be associated with promising results in patients with recurrent ovarian cancer. Large international prospective studies are required to further quantify the true efficacy of HIPEC and identify the optimal treatment protocol for a maximum survival benefit. |
| Databáze: | OpenAIRE |
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