Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training
| Autor: | Jason P. Edwards, Alexander T. Carswell, Sophie E Harrison, Lesley E. Rhodes, Laurel M. Wentz, William D. Fraser, Ross Roberts, Rachel M. Izard, Samuel J. Oliver, Daniel S. Kashi, Sarah E Jackson, Julie P. Greeves, Neil P. Walsh, Jonathan Tang, Donald Allan |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty 25-HYDROXYVITAMIN D Adolescent medicine.medical_treatment Administration Oral Physical Therapy Sports Therapy and Rehabilitation EXERCISE IMMUNITY Placebo law.invention Cathelicidin RC1200 03 medical and health sciences Young Adult 0302 clinical medicine Randomized controlled trial Double-Blind Method law RA0421 Internal medicine Surveys and Questionnaires medicine Vitamin D and neurology Humans CHOLECALCIFEROL Orthopedics and Sports Medicine Immunity Mucosal Respiratory Tract Infections Sunlight business.industry Applied Sciences Respiratory infection Common cold 030229 sport sciences medicine.disease Upper respiratory tract infection Military Personnel VIRUS Female business UVB |
| Zdroj: | Medicine and Science in Sports and Exercise |
| ISSN: | 1530-0315 |
| Popis: | Purpose This study aimed to determine the relationship between vitamin D status and upper respiratory tract infection (URTI) of physically active men and women across seasons (study 1) and then to investigate the effects on URTI and mucosal immunity of achieving vitamin D sufficiency (25(OH)D ≥50 nmol·L−1) by a unique comparison of safe, simulated sunlight or oral D3 supplementation in winter (study 2). Methods In study 1, 1644 military recruits were observed across basic military training. In study 2, a randomized controlled trial, 250 men undertaking military training received placebo, simulated sunlight (1.3× standard erythemal dose, three times per week for 4 wk and then once per week for 8 wk), or oral vitamin D3 (1000 IU·d−1 for 4 wk and then 400 IU·d−1 for 8 wk). URTI was diagnosed by a physician (study 1) and by using the Jackson common cold questionnaire (study 2). Serum 25(OH)D, salivary secretory immunoglobulin A (SIgA), and cathelicidin were assessed by liquid chromatography–mass spectrometry LC-MS/MS and enzyme-linked immunosorbent assay. Results In study 1, only 21% of recruits were vitamin D sufficient during winter. Vitamin D–sufficient recruits were 40% less likely to suffer URTI than recruits with 25(OH)D 0.05). Supplementation did not affect salivary secretory immunoglobulin A or cathelicidin. Conclusion Vitamin D sufficiency reduced the URTI burden during military training. |
| Databáze: | OpenAIRE |
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