Associations of vascular calcification, calcium phosphate disturbances, FGF 23 and Matrix Gla protein with mortality of hemodialysis patients: one center cohort study
| Autor: | Inga Arune Bumblyte, Egle Jonaitiene, Edita Ziginskiene, Vytautas Kuzminskis, Erika Skrodeniene, Saulius Grazulis, Ruta Vaiciuniene, Vaida Petrauskiene |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Fibroblast growth factor 23
medicine.medical_specialty medicine.medical_treatment 030232 urology & nephrology mgp chemistry.chemical_element 030204 cardiovascular system & hematology Calcium survival 03 medical and health sciences 0302 clinical medicine Internal medicine Matrix gla protein Medicine Vascular calcification hemodialysis biology business.industry Endocrinology chemistry biology.protein sense organs fgf 23 Hemodialysis business mineral metabolism disorders Cohort study |
| Zdroj: | Romanian Journal of Laboratory Medicine, Vol 26, Iss 4, Pp 451-460 (2018) |
| ISSN: | 2284-5623 |
| DOI: | 10.2478/rrlm-2018-0034 |
| Popis: | Background and objectives: Vascular calcification (VC) is one of the factors associated with mortality in hemodialysis (HD) patients. The purpose of the study was to assess associations between prevalent VC and disturbances of calcium-phosphate metabolism as well as changes in vitamin D (25(OH)D), FGF 23 and MGP levels and to evaluate the possible impact of VC and changes of these biomarkers on survival in HD patients. Methods: The study population consisted of 81 prevalent patients in the hemodialysis unit of Hospital of Lithuanian University of Health Sciences Kaunas Clinics. A simple vascular calcification score (SVCS) was evaluated as it is described by Adragao et al. 25(OH)D (nmol/L), FGF 23 (ng/L) and MGP (ng/mL) were measured and analysed. Results: Patients were divided into two groups: SVCS Conclusion: VC in HD patients is highly influenced by age and presence of diabetes and associated with higher risk of death. No significant association was found between MGP and FGF 23 and VC as well as between these two biomarkers and risk of death. Lower 25(OH)D levels were associated with mortality in this dialysis patients cohort. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|