| Autor: |
Scott W. Lowe, Christopher R. Vakoc, Agustin Chicas, Vishal Thapar, Myles Fennell, Chi-Chao Chen, Jessica E. Bolden, Ozlem Aksoy, Chun-Hao Huang, Darjus F. Tschaharganeh, Matthew Camiolo, Direna Alonso-Curbelo, Jae-Seok Roe, Ana Banito, Nilgun Tasdemir |
| Rok vydání: |
2023 |
| DOI: |
10.1158/2159-8290.22531508.v1 |
| Popis: |
Supplementary Figure S1. Senescence-activated SASP enhancers are marked by H3K4Me1 in proliferating IMR90 cells. Supplementary Figure S2. Reproducibility analyses of biological replicates for H3K27Ac and BRD4 ChIP-Seq. Supplementary Figure S3. Enhancer remodeling during oncogene-induced senescence parallels gene expression changes. Supplementary Figure S4. Genetic and pharmacologic inhibition of BRD4 impairs SASP gene expression during oncogene-induced senescence (OIS). Supplementary Figure S5. BRD4 couples enhancer remodeling to SASP gene expression during etoposide-induced senescence. Supplementary Figure S6. Systemic and cell-autonomous suppression of Brd4 impairs the immune surveillance of senescent hepatocytes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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