Identity of Antibody to Hepatitis B e/1 Antigen as an Atypical Rheumatoid Factor
| Autor: | Victor M. Villarejos, Kirsten Anderson-Visoná |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
HBsAg
Hemagglutination Antibodies Viral Immunoglobulin G Hepatitis B Antigens Epitopes Antigen Antibody Specificity Rheumatoid Factor Humans Immunology and Allergy Medicine Rheumatoid factor Hepatitis B Antibodies Hepatitis B Surface Antigens biology business.industry Hepatitis B medicine.disease Virology Infectious Diseases Immunoglobulin M Carrier State Immunology biology.protein Antibody business Viral hepatitis |
| Zdroj: | Journal of Infectious Diseases. 141:603-608 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/141.5.603 |
| Popis: | Chronic carriers of hepatitis B surface antigen (HBsAg) who were positive for antibody to hepatitis B e antigen were tested for precipitating specificities of the antibody and for rheumatoid factor (RF) over a two-year period. Twenty-one of 69 carriers were RF-positive by the latex-RF test with human IgG, but all were negative by the hemagglutination-RF test with rabbit IgG. Antibody to e/1 antigen was identified as an IgM antibody reactive in the latex-RF test, whereas antibody to e/2 antigen belonged to the IgG class and showed no RF reactivity. Antibody production seems to follow a sequential evolution: antibody to e/1 antigen appears early and that to e/2 antigen follows shortly thereafter. Antibody to e/2 antigen remains as the permanent antibody, whereas that to e/1 antigen sometimes disappears. The fact that antibody to e/1antigen is present only in certain chronic carriers of HBsAg would account for discrepancies in reported results of RF test in viral hepatitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|