Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation?

Autor:	Daniela Ligi, Rosanna Maniscalco, Mario Plebani, Giuseppe Lippi, Ferdinando Mannello
Rok vydání:	2022
Předmět:	laboratory medicine neutrophil extracellular trap COVID-19 Histones COVID-19 Coagulopathy Hyperinflammation General Medicine histone Hyperinflammation heparin coagulopathy Histones Coagulopathy cytokine storm heparinoids inflammation multiorgan injury
Zdroj:	Journal of clinical medicine. 11(7)
ISSN:	2077-0383
Popis:	Several studies shed light on the interplay among inflammation, thrombosis, multi-organ failures and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Increasing levels of both free and/or circulating histones have been associated to coronavirus disease 2019 (COVID-19), enhancing the risk of heart attack and stroke with coagulopathy and systemic hyperinflammation. In this view, by considering both the biological and clinical rationale, circulating histones may be relevant as diagnostic biomarkers for stratifying COVID-19 patients at higher risk for viral sepsis, and as predictive laboratory medicine tool for targeted therapies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798cc926502f78f57a0b52912d963884 https://pubmed.ncbi.nlm.nih.gov/35407410 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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