HMB-45/Melan-A and Smooth Muscle Actin-Positive Clear-Cell Epithelioid Tumor Arising in the Ligamentum Teres Hepatis
| Autor: | Yukio Nakatani, Yukichi Tanaka, Kazuaki Misugi, Rieko Ijiri, Yoshikazu Kato, Masamichi Hara, Keisuke Kato |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pathology
medicine.medical_specialty Adolescent Vimentin Biology Perivascular Epithelioid Cell Pathology and Forensic Medicine Cytokeratin MART-1 Antigen Antigens Neoplasm medicine Humans Nuclear atypia Ligaments Epithelioid Cells Liver Neoplasms Immunohistochemistry Actins Neoplasm Proteins HMB-45 Microscopy Electron Clear-Cell Sugar Tumors biology.protein Female Surgery Desmin Anatomy Melanoma-Specific Antigens Clear cell Adenocarcinoma Clear Cell |
| Zdroj: | The American Journal of Surgical Pathology. 24:1295-1299 |
| ISSN: | 0147-5185 |
| DOI: | 10.1097/00000478-200009000-00015 |
| Popis: | HMB-45-positive clear-cell epithelioid tumor arising in the ligamentum teres hepatis of a 13-year-old Japanese girl is described. The well-defined tumor was completely removed and measured 9 x 7 x 6 cm. Cut sections showed a tan-white, homogeneous appearances with no hemorrhage or necrosis. The tumor was composed of nests or sheets of polygonal or oval-shaped cells rich in clear or finely granular cytoplasm. Capillary network was well developed, and sinusoid vessels were often seen with occasional perivascular hyalinization. There was moderate nuclear atypia but mitotic figures were absent. Periodic acid-Schiff stain showed a large amount of glycogen digested by diastase. Immunohistochemical stains for smooth muscle actin, Melan-A, and HMB-45 were positive in most of the tumor cells. Stains for vimentin, muscle actin, and HAM56 were focally positive, whereas stains for desmin, cytokeratin, epithelial membrane antigen, S-100, CD34, CD68, CD99, neurofilament proteins, and estrogen/progesterone receptors were negative. Ultrastructurally, the cytoplasm contained a considerable number of mitochondria, monoparticipate or membrane-bound glycogen, and longitudinally oriented thin filaments with focal condensations and subplasmalemmal densities. The histopathology of the present case, originally interpreted as epithelioid leiomyoma, was consistent with clear cell "sugar" tumors. The present case may indicate ubiquitous distribution of clear cell "sugar tumors" of which histogenesis remains unknown but is presumed to be of perivascular epithelioid cell origin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|