Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013

Autor: Iram P. Rodriguez-Sanchez, Jesús Gómez-Carballo, Laura Conde-Ferráez, Guadalupe Ayora-Talavera, Luisa López-Ochoa, Maria Chan-Gasca, Jorge H. Ramirez-Prado, Marylin Puerto-Solís, Pilar Granja-Pérez, Bertha Jiménez-Delgadillo, José Reyes Canché-Pech, Salha Villanueva-Jorge, Refugio González-Losa
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
RNA viruses
Influenza Viruses
Viral Diseases
Genes
Viral
viruses
lcsh:Medicine
Pathology and Laboratory Medicine
Geographical locations
Database and Informatics Methods
Influenza A Virus
H1N1 Subtype
Medicine and Health Sciences
lcsh:Science
Clade
Data Management
Multidisciplinary
biology
Microbial Mutation
Microbial Genetics
Phylogenetic Analysis
Phylogenetics
Infectious Diseases
Medical Microbiology
Viral Pathogens
Viruses
Seasons
Pathogens
Sequence Analysis
Research Article
medicine.medical_specialty
Computer and Information Sciences
Bioinformatics
Hemagglutinin (influenza)
Research and Analysis Methods
Microbiology
History
21st Century
Virus
03 medical and health sciences
Amino Acid Sequence Analysis
Molecular genetics
Genetic variation
Influenza
Human
medicine
Genetics
Humans
Evolutionary Systematics
Gene
Mexico
Microbial Pathogens
Taxonomy
Evolutionary Biology
lcsh:R
Organisms
Biology and Life Sciences
Genetic Variation
Virology
Influenza
030104 developmental biology
North America
biology.protein
Microbial genetics
lcsh:Q
People and places
Neuraminidase
Orthomyxoviruses
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 12, p e0189363 (2017)
ISSN: 1932-6203
Popis: The 2012 and 2013 annual influenza epidemics in Mexico were characterized by presenting different seasonal patterns. In 2012 the A(H1N1)pdm09 virus caused a high incidence of influenza infections after a two-year period of low circulation; whereas the 2013 epidemic presented circulation of the A(H1N1)pdm09 virus throughout the year. We have characterized the molecular composition of the Hemagglutinin (HA) and Neuraminidase (NA) genes of the A(H1N1)pdm09 virus from both epidemic seasons, emphasizing the genetic characteristics of viruses isolated from Yucatan in Southern Mexico. The molecular analysis of viruses from the 2012 revealed that all viruses from Mexico were predominantly grouped in clade 7. Strikingly, the molecular characterization of viruses from 2013 revealed that viruses circulating in Yucatan were genetically different to viruses from other regions of Mexico. In fact, we identified the occurrence of two genetic variants containing relevant mutations at both the HA and NA surface antigens. There was a difference on the temporal circulation of each genetic variant, viruses containing the mutations HA-A141T / NA-N341S were detected in May, June and July; whereas viruses containing the mutations HA-S162I / NA-L206S circulated in August and September. We discuss the significance of these novel genetic changes.
Databáze: OpenAIRE
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